Fig. 4
From: Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment
NMU induces the motility of macrophages. a TDM and MDM chemotaxis towards NMU-9. b Expression of the polarization marker HLA-DR for the M1 phenotype and CD206 for the M2 phenotype on macrophages treated with NMU-9. The results are shown as the means with SD (HLA-DR: paired t test: p = 0.6752; n = 4; CD206: paired t test: p = 0.0047; n = 5). c Migration of TDMs (left panel) and MDMs (right panel) treated with NMU-9 (columns on the left) or CM from HT29 cells secreting NMU (columns on the right). The results are presented as the means with SD (paired t test: *p ≤ 0.05; **p ≤ 0.01; n ≥ 4). The images show representative results (scale bar = 100 µm)