Fig. 2
Transcriptomic landscape of the genes in TGF-β superfamily signaling module in human bone marrow-derived MSCs. The transcripts of selected genes were extracted from GSE94736, a transcriptomic dataset from healthy human bone marrow-derived MSCs. The converted TPM values for each gene were presented in Additional files 2 to 4. For the graphic presentation, the data were transformed to log-space by taking log2 (TPM + 1) (as described in Materials & Methods). The genes were grouped into type I receptors (A), type II receptors (B), SMADs (C), TGF-β superfamily ligands known to mediate SMAD2/3 signaling (D), TGF-β superfamily ligands known to mediate SMAD1/5/8 signaling (E), and antagonists (F). The gene rankings in each group were arranged in an ascending order based on their expression levels. For the groups, such as ligands and antagonists, exhibiting diverse ranges of expression, a TPM cutoff value was set at 0.5 (gray dashed line). The genes with values less than the cutoff were placed independently in gray dashed boxes. Each gene expression level was expressed as means (black line) ± S.D. n = 28