Table 1 Type of effective MiRNAs in POF

1. Mir23a

Both TRERNA1 and miR-23a were downregulated in POF

[92,93,94,95,96,97]

2. miR-146b-5p

Increased DLEU1 expression and decreased miR-146b-5p expression were observed in POF. DLEU1 promoted cell apoptosis and reduced the inhibitory effects of miR-146b-5p on cell apoptosis

[93, 98,99,100]

3. MiR-144-5p

exosomal miR-144-5p in BMSCs was able to directly target PTEN, a protein involved in the apoptosis of CTX-damaged GCs. PTEN has been shown to negatively regulate the PI3K/AKT pathway and induce apoptosis or cell cycle arrest at the G1 phase

[101,102,103,104,105]

4. miR-15b

overexpression of miR-15b induces POI by silencing the endogenous α-Klotho mRNA and stimulating the activity of the downstream transforming growth factor β1 (TGFβ1)/SMAD pathway

[106,107,108]

5. miR-146a

miR-146a contributes to the apoptosis of ovarian granulosa cells via the caspase cascade by directly targeting IRAK1 and TRAF6

[109,110,111,112,113]