Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer

Fig. 5

Top interactions between cancer-associated fibroblasts (CAFs) and epithelial cells have multiple ligands and receptors associated with the PI3K-AKTsignaling pathway and focal adhesion. A Top ligand-receptor interactions (Commun. Probability > 0.10) between CAFs and epithelial cells. Heatmaps show the EnrichR pathway enrichment analysis for gene sets that define all CAFs ligands B and epithelial cell receptors C. The top 10 pathway terms (lowest adjusted P-value) were chosen from WikiPathways 2021 and MSigDB Hallmark 2020 libraries available in EnrichR [30, 31]. D PI3K-AKT ligand-receptor interactions between CAFs and epithelial cells. E Top ligand-receptors interactions (Commun. Probability > 0.10) between epithelial cells and CAFs. Heatmaps showing the EnrichR pathway enrichment analysis for gene sets that define all epithelial cells ligands F and CAFs receptors G. The top 10 pathway terms (lowest adjusted P-value) were chosen from WikiPathways 2021 and MSigDB Hallmark 2020 libraries available in EnrichR [30, 31]. Commun. Prob., communication probability

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X