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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer

Fig. 4

Cancer-associated fibroblasts (CAFs) receive a specific communication pattern from malignant effusion cells associated with the differentiation pathway and EGFR tyrosine kinase inhibitor resistance. Incoming patterns for signaling A, cell B, and communication C of multiple cell types in malignant abdominal fluids of ovarian cancer patients obtained with CellChat [35] from scRNA-seq data [17]. The asterisks in C indicate pathways not associated with CAFs and epithelial cells communication (communication pattern 1, cluster 2). This communication pattern 1 (cluster 2) was used to identify pathways for gene sets of cells ligands D and CAFs receptors for these ligands E. In both D and E, the focal adhesion-PI3K-AKT-mTOR are among the top altered pathways. The top 10 pathway terms (lowest adjusted P-value) were selected from WikiPathways 2021 and MSigDB Hallmark 2020 libraries available in EnrichR [30, 31]

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Cell Communication and Signaling

ISSN: 1478-811X