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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancer

Fig. 2

Single-cell transcriptomics re-analysis confirm the heterogeneity of cancer-associated fibroblasts (CAFs) in ovarian cancer malignant ascites. A Single-cell RNA-sequencing (scRNA-seq) data visualization of four CAFs populations using t-distributed stochastic neighbor embedding (tSNE). B Violin plots show the expression levels of canonical CAFs markers in CAFs populations, including myofibroblastic cancer-associated fibroblasts (myCAF1-2) and inflammatory cancer-associated fibroblasts (iCAF1-2). C Heatmap shows the pathway enrichment analysis (EnrichR [30, 31]) for gene sets of cluster-specific CAFs markers. Top 25 pathway terms (lowest adjusted P-value) selected from the WikiPathways 2021 and MSigDB Hallmark 2020 libraries available in EnrichR [30, 31]. D Violin plots show the expression levels of ovarian cancer CAFs markers among the four CAFs populations

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Cell Communication and Signaling

ISSN: 1478-811X