Fig. 7From: JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathwaySchematic diagram of the JAK1-HIF-1/2α pathway in EC. Left: In normal cells, JAK1 downregulates the expression of HIF-1/2α. Right: In EC cells, JAK1 LOF mutations promote EC tumorigenesis via activating HIF signaling pathwayBack to article page