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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Fig. 6

JAK1 knockdown elevates the expression of HIF downstream genes in KLE cells. A RT-qPCR measurement of the mRNA expression of HIF downstream genes in parental and JAK1-knockdown KLE cells. The cells were incubated under hypoxia (2% O2). After hypoxia for 0, 2 h, 4 h, cells were harvested, respectively. Data are shown as the mean ± SD (n = 3). B RT-qPCR measurement of the mRNA expression of HIF downstream genes in different KLE cells. The cells were treated with DMSO or Ruxolitinib (1 μmol) for 48 h. Then cells were incubated under hypoxia (2% O2). After hypoxia for 0, 2 h, 4 h, cells were harvested, respectively. Data are shown as the mean ± SD (n = 3)

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Cell Communication and Signaling

ISSN: 1478-811X