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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Fig. 1

JAK1 is frequently mutated and downregulated in EC. A Schematics of the JAK1 proteins show the positions of individual somatic mutations identified in the endometrial cancer TCGA cohort. B JAK1 mutations were more frequently detected in the microsatellite instability (MSI) subgroup and POLE-mutated subgroup. C The relative mRNA expression of JAK1 in normal endometrial tissues and endometrial cancer tissues from TCGA cohort. D Representative images of JAK1 IHC in normal and EC specimens. Original magnification 200×, scale bar, 100 μm (left); 400×, scale bar, 50 μm (right). E Immunohistochemistry scores (IS) of JAK1 in normal endometrium (n = 20) and EC tissues (n = 45)

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Cell Communication and Signaling

ISSN: 1478-811X