Fig. 2
Transcriptional profiles in BRAFV600E mutant MaMel cells. A Principal component analysis (PCA) for the transcriptomic profiles from MaMel cells. The projections of the first two principal components (PC1–PC2) are shown, with the percentage of variance explained by each one indicated in brackets. B Self-organizing maps of MaMel transcriptomes. Clusters of over- (red) and under- (blue) expressed genes are indicated with black arrows. Significantly enriched (p < 0.05) biological processes are annotated for each cluster. C Enrichment of proliferative and invasive melanoma signatures [21, 22] in MaMel cells. D Normalized expression (z-score) from genes corresponding to the proliferative and invasive melanoma signatures