Skip to main content
Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes

Fig. 2

NK cell function in patients with MDS is decreased when TIGIT expression is increased. A. The expression of NKG2D, Perforrin, CD107a and IFN-γ in MDS patients were decreased compared to those in HCs. B. The expression of inhibitory receptors TIM-3, PD-1, TIGIT, CD96, LAG-3 and VISTA of NK cells in MDS patients. C. TIGIT RNA expression in normal human tissue plotted as RPKM. Data were obtained from the Human Protein Atlas Dataset available from proteinatlas.org. D. The expression of TIGIT was significantly increased on NK cells in MDS patients compared to that in HCs, whereas CD226 expression was decreased. The dot plots are the statistics of the expression of TIGIT and CD226, including patients with HCs (n = 44) and MDS patients (n = 50).* indicates a significant difference compared with the HC group, P < 0.05. ** indicates a significant difference compared with the HC group, P < 0.001. NK, natural killer; MDS, myelodysplastic syndrome; TIGIT, T cell immunoglobulin and ITIM domain; HCs, healthy controls; RPKM, rates per kilobase million

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X