Fig. 2

The life cycle of SARS-CoV-2 in host cells; The life cycle of the virus begins with the binding of the S1 protein to the cellular receptor ACE2, followed by proteolytic cleavage that makes the S2 protein facilitate the fusion of the viral and cellular membranes. Within the cell, viral RNA replicates, followed by viral proteins translating from the RNA, followed by the assembly of viral proteins and genome within the endoplasmic reticulum and Golgi. Virions are eventually transported to the cell membrane by vesicles and released by budding from the cytoplasmic membrane