Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway

Fig. 5

Inhibition of NRF2 improves sensitivity to DNR in DNMT3A R882H mutant cells. A, B Apoptosis rate was measured by flow cytometry in KG-1a and THP1 cells expressing WT and R882H after treatment with 40 nM brusatol. C–E Mutant KG-1a and THP1 cells were exposed to different concentrations of brusatol for 24 h to detect the expressions of NRF2, NQO1 and apoptosis-related proteins. F The expressions of NRF2, NQO1 and apoptosis related proteins were detected by Western blotting after treatment of KG-1a and THP1 mutant cells with DNR and brusatol. G–I The role of brusatol or DNR-brusatol combination on cell viability and cell apoptosis in KG-1a and THP1 mutant cells

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X