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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway

Fig. 4

DNMT3A R882H mutation regulated the stability of NRF2. A Bisulfite sequencing analysis of the promoter-related CPG island of NRF2 in KG-1a cells expressing DNMT3A NC, WT, and R882H. B KG-1a cells expressing DNMT3A WT and DNMT3A R882H were incubated with CHX (10 μg/mL) at indicated times and the expression of NRF2 was detected by western blotting. C Total proteins extracted from KG-1a cells (NC, WT, R882H) were immunoprecipitated with anti-NRF2 antibody and immunoblotted with anti-DNMT3A and anti-NRF2 antibodies

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Cell Communication and Signaling

ISSN: 1478-811X