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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway

Fig. 2

DNMT3A R882H mutation confers resistance to daunorubicin. A, B KG-1a and THP1 cells stably expressing DNMT3A-WT and the mutant were exposed to DMSO and DNR (0.4 μM) for 36 h and used for apoptosis analysis. C, D Sensitivity to DNR in KG-1a and THP1 cells expressing DNMT3A-WT and the mutant E, F Analysis of apoptosis related proteins in KG-1a and THP1 cells expressing DNMT3A mut and wild-type and treated with different concentrations of daunorubicin for 36 h. G, H Analysis of apoptosis related proteins in KG-1a and THP1 cells expressing DNMT3A mut and wild-type at different time points (0, 6, 12, 24, 48 h) after daunorubicin (0.4 μM) treatment

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Cell Communication and Signaling

ISSN: 1478-811X