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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

Fig. 6

Model of the functional interplay between matrix stiffness and MRTF-A activity. Increasing matrix stiffness correlates with increased MRTF-A activity, enhanced protrusion formation and luminal filling. Alteration of the Rho/MRTF/SRF pathway reduces protrusions, indicating that MRTF-A is required but not sufficient for protrusion formation. In addition, increased MRTF-A activity promotes luminal filling independent of matrix stiffness in mammary organoids

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Cell Communication and Signaling

ISSN: 1478-811X