Fig. 4
From: PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models
Celecoxib inhibits the macrophages activation in the CNV lesions. A The proportion of CD206 + or CD80 + cells among CD11b-gated monocytes derived from the laser-induced mice at 7 dpi was detected by flow cytometric analyses. B Column diagram is the percentages of the populations of CD11b-gated CD206 + or CD80 + in flow cytometric analyses (n = 6). C–E Immunofluorescence staining of choroidal sections and flat mounts from mice at 7 dpi with anti-CD206, anti-CD80 and F4/80 mAbs; scale bar: 100 μm. F, G The mRNA levels of the M1 and M2-specific markers were measured at 7 dpi by qRT-PCR in the RPE-choroid complex (n = 6). *P < 0.05, **P < 0.01 vs. Con; and #P < 0.05, ##P < 0.01 vs. AMD; and @P < 0.05 vs. AMD