Fig. 3
From: PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models
Celecoxib attenuates CNV in the mouse model of AMD. A Representative images of the vascular leakage at 7 dpi and 14 dpi are displayed. B Quantification of vascular leakage spots (n = 6). C The cross-sectional OCT and fundus images at 7 dpi and 14 dpi. D Immunofluorescence staining of the flat mounts from the mice at 7 dpi and 14 dpi with anti-IB4 mAbs. E Quantification of the CNV lesion area in the choroidal flat mounts (n = 6). F, G H&E staining of the paraffin sections of the choroidal Sects. (14 dpi) with quantification (n = 6). H, I The mRNA levels of Vegfa and Pdgf were measured in the RPE-choroid complex at 7 dpi by qRT-PCR (n = 6). Scale bar: 100 μm D and F. *P < 0.05; **P < 0.01