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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Fig. 4

Schematic representation of the crosstalk between activated lymphocytes and hepatocytes, following the ConA administration, thereby liver injury. On the one hand, the inflammatory cytokines secreted from the ConA-induced lymphocytes would induce the cell-death functions of STAT3 in hepatocytes, which activates BNIP3, then autophagy and apoptosis induction. On the other hand, the anti-inflammatory cytokines would stimulate mitogenic functions of STAT3, leading to the up-regulation of mitogenic and anti-apoptosis genes

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Cell Communication and Signaling

ISSN: 1478-811X