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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Fig. 3

Cartoons represent the molecular mechanism of the proliferative effects induced by ConA in fibroblasts, lymphocytes, and MSCs. The lectin acts as an agonist for TLR-2, TLR-6, and PZR receptors, which all induce the SHP-2/c-Ras axis as their main downstream effector following ConA treatment to activate the mitogenic functions of STAT3 and ERK1/2 signaling molecules

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