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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Fig. 1

The 3-D structure of the native form of ConA monomer (1NLS) presents the jellyroll motif. ConA is the foremost characterized leguminous lectin as it is the first isolated lectin. Its monomer has a molecular rate of ~ 25 KDa, with 237 residues, arranging a canonical 12-stranded β-sandwich structure. Of note, the oligomerization status of the lectin depends on the pH values. The green circle indicates the carbohydrate recognition domain (CRD) in which the involved residues are illustrated as sticks; the orange circle shows the metal binding site (MBS) interacting with two metal ions, Ca2+ (in green) and Mn2+ (in purple), that play a pivotal role in lectin stability

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Cell Communication and Signaling

ISSN: 1478-811X