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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic inflammatory responses via NF-kappa B activation in acute pancreatitis

Fig. 2

Pharmacological inhibition of S1PR2 by JTE-013 alleviates the severity of pancreatic injury in acute pancreatitis mice. Schematic representation of the experimental schedule (A); serum lipase (B) and serum amylase (C) levels; ELISA of serum IL6 (D) and TNF-α (E); H&E-staining of pancreas sections (F); TUNEL staining(G); Western blot of pancreatic PARP, cleaved-caspase3 and NF-κB p65 (H) levels in the pancreas; Ly6G staining (I); CD68 staining (J). Data shown are means ± SEM. ***p < 0.001 compared with the control group. ##p < 0.05 compared with the model group

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Cell Communication and Signaling

ISSN: 1478-811X