Fig. 3
From: Endoplasmic reticulum stress targeted therapy for breast cancer
UPR Signaling in HER2+ BC. In HER2+ BC cells, HER2 amplification can activate the UPR through the PERK-ATF4-CHOP-TRAIL-R2 pathway, and the PERK-ATF4-ZEB1-E-cadherin pathway can regulate cell apoptosis and migration. Meanwhile, HER2-mTOR signaling can activate the IRE1 pathway. The drugs targeting ERS-associated signaling pathways in HER2+ BC are listed. Green represents pathway activators