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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: ARID1A deficiency reverses the response to anti-PD(L)1 therapy in EGFR-mutant lung adenocarcinoma by enhancing autophagy-inhibited type I interferon production

Fig. 4

ARID1A knockdown enhances production of type I interferon via the Rig-I-like receptor pathway in EGFR-mutant lung adenocarcinoma cells. A GSEA revealed activation of the Rig-I-like receptor pathway; RNA-seq demonstrated upregulation of IRF7. B Relative expression of phosphorylated proteins enriched in the MAPK pathway revealed by mass spectrometry. C Relative expression of phosphorylated NF-κB pathway biomarkers revealed by mass spectrometry. D RNA-seq sequencing and mass spectrometry revealed upregulation of interferon-induced proteins. E Expression evaluation of targeted proteins revealed by western blotting. F GSEA revealed the enhancement of the response to interferon γ in ARID1A knockdown lung adenocarcinoma cells

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Cell Communication and Signaling

ISSN: 1478-811X