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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: ARID1A deficiency reverses the response to anti-PD(L)1 therapy in EGFR-mutant lung adenocarcinoma by enhancing autophagy-inhibited type I interferon production

Fig. 2

Exploration of biological processes and pathways related to low ARID1A expression in EGFR-mutant lung adenocarcinoma cell lines using a multiomics method. A Evaluation of ARID1A protein expression after construction of the ARID1A knockdown cell line. B PCA based on RNA samples for RNA-seq sequencing. C Volcano plot shows differentially expressed genes revealed by RNA-seq sequencing. D Heatmap for differentially expressed genes revealed by RNA-seq sequencing; E1, E2 Enrichment analysis based on upregulated genes in ARID1A knockdown cells revealed by RNA-seq sequencing. F Enrichment analysis based on differentially expressed proteins revealed by mass spectrometry for upregulated phosphorylated proteins in ARID1A-knockdown cells

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Cell Communication and Signaling

ISSN: 1478-811X