Fig. 7

Schematic diagram of the ABCB1 binding with MRTX849 and the reversal of ABCB1-mediated MDR by MRTX849. A Overview of the patterns of the MRTX849 binding with ABCB1. B MRTX849 was depicted as purple, the white indicates amino acids residues of nucleotide-binding domains (NBD) in ABC transporters. C The comparison of MRTX849 and ATP in binding with ABCB1, ATP was displayed as yellow, MRTX849 was depicted as purple. D MRTX849 competed with the transporter substrate drugs to interact with the substrate-binding sites, thus increasing cellular accumulation of the drugs and circumvention of MDR