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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Adagrasib, a KRAS G12C inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo

Fig. 5

Effect of MRTX849 on ABCB1 expression level in MDR cells. A, B ABCB1-overexpressing MDR cells were incubated with MRTX849 at various concentrations or time points. MRTX849 had no effect on ABCB1 protein level measured by Western blot assay. C, D MRTX849 had no effect on ABCB1 mRNA expression measured by qPCR assay. E, F MRTX849 did not change ABCB1 expression on cell surface measured by flow cytometry. G The subcellular localization pattern of ABCB1 was evaluated using confocal laser scanning microscopy. ABCB1 (green) and nuclei (DAPI, blue) were visualized

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Cell Communication and Signaling

ISSN: 1478-811X