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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Adagrasib, a KRAS G12C inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo

Fig. 4

Effect of MRTX849 on the efflux of Rho 123, ABCB1 ATPase activity and [125I]-IAAP photoaffinity labeling of ABCB1. A, B Rho 123 efflux at different time points was monitored in KB, KBv200 cells or MCF-7, MCF-7/adr cells after treatment with or without 1 μM MRTX849. C Effect of MRTX849 on ABCB1 ATPase activity. D MRTX849 competed for photolabeling of ABCB1 by [125I]-IAAP

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Cell Communication and Signaling

ISSN: 1478-811X