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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Adagrasib, a KRAS G12C inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo

Fig. 3

Effect of MRTX849 on intracellular accumulation of substrate agents in ABCB1-overexpressing MDR cells and sensitive cells. A-D The intracellular accumulation of Rho123 in KB, KBv200 cells or MCF-7, MCF-7/adr cells and that of Dox in KB, KBv200 cells or MCF-7, MCF-7/adr cells. Data are shown as fold-change in fluorescence intensity relative to untreated control MDR cells. *P < 0.05, **P < 0.01, *** P < 0.001, compared with control

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Cell Communication and Signaling

ISSN: 1478-811X