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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy

Fig. 8

Schematic illustration depicting how TRIM31 acts upon NLRP3 inflammasome activation in Hp-associated gastritis by regulating ROS and autophagy. TRIM31 is downregulated in chronic Hp-associated gastritis. Increased ROS, impaired autophagy flux, and decreased levels of lysosomal cathepsin B and cathepsin D were observed in TRIM31-deficient GES-1 cells with Hp infection. TRIM31 suppressed the activation of the NLRP3 inflammasome by affecting ROS and autophagy in Hp infection

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Cell Communication and Signaling

ISSN: 1478-811X