Fig. 1
From: Review of potential medical treatments for middle ear cholesteatoma
The proinflammatory intra and extracellular signalling in MEC disease. The orange background symbolizes the MEC, red represents the cytoplasm of residing cells and brown their nucleus. The level of evidence linking the depicted part of the pathway to MEC parthenogenesis are color-coded (red, yellow and green), proinflammatory deregulation is shown in blue. Fractions which were not investigated so far but bound to be a vital part of the proinflammatory signalling in MEC are shown in white. The pharmaceutical treatment options accessible within the inclusion criteria chosen in this review are shown as blue/red pills