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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway

Fig. 9

Schematic model for how MICAL2 regulates E-cadherin degradation and β-catenin-mediated cell migration. In brief, MICAL2 was identified as a novel key molecule implicated in gastric cancer cell migration. MICAL2 increased E-cadherin ubiquitination and degradation in a Cdc42-dependent manner, thereby leading to enhanced β-catenin signaling via the disruption of the E-cadherin/β-catenin complex and, consequently, the promotion of gastric cell migration

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Cell Communication and Signaling

ISSN: 1478-811X