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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway

Fig. 4

The effect of MICAL2 overexpression on epithelial-to-mesenchymal (EMT)-related marker proteins. A–D SGC-7901 cells were transfected with empty vector or a MICAL2 expression plasmid, after which the levels of MICAL2 (A), E-cadherin (B), vimentin (C), and N-cadherin (D) were measured by qPCR and western blotting. E Representative image of transwell assays in SGC-7901 cells transfected with empty vector or a MICAL2 expression plasmid. Cells on the lower surface of the membrane were quantified in three randomly selected fields and are shown in the panels on the right. F Representative image of wound healing assays in MICAL2-overexpressing SGC-7901 cells (n = 5 per group). Data are presented as means ± SD of the wound area relative to the control group. *P < 0.05, **P < 0.01, ***P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X