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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

Fig. 3

Links between metabolism and the microenvironment. Cancer cells change the extracellular milieu's chemical composition, which has pleiotropic effects on the phenotypes of cells around the tumor and the extracellular matrix. The microenvironment influences the metabolic and signaling responses of cancer cells reciprocally. MMPs: matrix metalloproteinases, AhR: aryl -hydrocarbon receptor, HA, hyaluronic acid, MCT1: monocarboxylate transporter 1, Kyn, kynurenine, TDO2: tryptophan-2, 3-dioxygenase 2, IDO1: indoleamine-2, 3-dioxygenase 1, CAIX: carbonic anhydrase IX, Treg: regulatory T cells, ECM: extracellular matrix

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Cell Communication and Signaling

ISSN: 1478-811X