Fig. 2From: The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumorsInteractions between metabolism and the tumor microenvironment. The chemical properties of the extracellular space are altered by cancer cells, which has complex effects on the characteristics of normal cells in the tumor microenvironments, as well as the extracellular matrix. In addition, the cancer cells; metabolic and signaling responses are influenced by the microenvironmentBack to article page