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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis

Fig. 3

Macrophage-derived exosomal miR-155-5p and miR-221-5p promote EC proliferation to help vascular angiogenesis. EC-derived exosomal circRNA007793 inhibits miR-622 to promote cell aging. LINC01005 promotes proliferation and migration of VSMCs by regulating the miR-128-3p/KLF4 axis, while ACE2 down-regulates the activated NF-kappaB pathway to inhibit this process. Notch3 promotes the aging of VSMCs to ease vasosclerosis through the mTOR signaling pathway. VSMC-derived exosomal miR-155 inhibits EC proliferation to prevent damage to the vascular endothelium

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Cell Communication and Signaling

ISSN: 1478-811X