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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis

Fig. 1

The miR-29b, LncH19/Runx2, miR-34a/TGF-β, and miR-128-3p/Wnt pathways promote the osteoblast phenotype to increase plaque stability. The miR-133a/Runx2, miR-204/miRr-211/BMP2, miR-125b/Ets-1, miR-223-3p/IL-6/STAT3, and miR-146a/TXNIP pathways reduce vascular calcification and senescence by inhibiting the phenotypic transition from VSMCs to osteoblasts and inducing plaque rupture

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