Fig. 2
From: Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives
Inflammation mechanism based on the secretion of sP-selectin and sCD40L in SARS-CoV-2 infection. Following infection of the airways of the lungs with the SARS-CoV-2, endothelial cells secrete sP-selectins that cause recruitment and activation of the platelets. More secretion of sP-selectin and sCD40L by activated platelets cause more activation of platelets and monocytes, and activation and antibody production by B lymphocytes. Inflammation is the final result of the activated platelets, monocytes, and B lymphocytes via this pathway