Fig. 10From: Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signallingProposed signalling cascades of α5-nAChR and PD-L1 involves in immune escape in lung cancer. Nicotine binds and interacts with α5-nAChR on the cell surface, activates STAT3/PD-L1 or STAT3/Jab1-PD-L1 signalling, thereby α5-nAChR/PD-L1 axis mediated immune cells activity in lung carcinogenesisBack to article page