Fig. 6
From: Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development
LIP overexpression induces ferroptosis through an increase in tfr1a and acsl4a. A-D SiRNA interference of zebrafish tfr1a. Representative phenotype (A), efficiency (B), survival rate (C) and phenotypic classification (D) of siRNA silenced zebrafish tfr1a. E–H SiRNA interference of zebrafish acsl4a. Representative phenotype (E), efficiency (F), survival rate (G) and phenotypic classification (H) of siRNA silenced zebrafish acsl4a. I-L SiRNA interference of zebrafish tfr1a and acsl4a. Representative phenotype (I), efficiency (J), survival rate (K) and phenotypic classification (L) of siRNA silenced zebrafish tfr1a and acsl4a. Data were given as means ± standard deviation. All figures are representative of three biological replicates (per test n = 100). ***, P < 0.001; **, P < 0.01; *, 0.01 < P < 0.05