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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Novel neoplasms associated with syndromic pediatric medulloblastoma: integrated pathway delineation for personalized therapy

Fig. 1

FAP syndromic desmoid fibromatosis arising 4 years after radiotherapy for MB. A MRI of a posterior fossa mass arising in floor of the 4th ventricle along the posterior aspect of the brainstem. B H&E shows the classic MB variant with abundant fresh hemorrhage. C Timeline of tumor progression and treatment. Rhomboid arrows indicate surgeries: intracranial in red, extracranial in orange; double slashes indicate interruption of the timeline for eventless periods; RT, radiotherapy; Chemo, chemotherapy. D CT of the epidural mass (red arrow) occurring 4 years post MB radiotherapy. E H&E of the epidural mass demonstrates an encapsulated hemorrhagic tumor composed of neoplastic fibroblastic cells embedded in a hyaline and myxoid ECM. Focal extramedullary hematopoiesis, showed magnified in inset, microvascular proliferation (black arrowhead) and mitotic activity (green arrowhead) are shown. β-catenin IHC shows diffuse and strong nuclear expression, indicating activation of the Wnt pathway

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Cell Communication and Signaling

ISSN: 1478-811X