From: THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
Factor | CDK7 expression | P value | |
---|---|---|---|
Low (112) | High (69) | ||
Age | |||
  < 60 | 58 | 42 | 0.233 |
  ≥ 60 | 54 | 27 |  |
Sex | |||
 Male | 51 | 36 | 0.385 |
 Female | 61 | 33 |  |
Tumor site | |||
 Stomach | 74 | 41 | 0.374 |
 Intestine, colorectal | 34 | 27 |  |
 Others | 4 | 1 |  |
Tumor size (cm) | |||
 0–5.0 | 63 | 35 | 0.725 |
 5.1–10.0 | 39 | 26 |  |
  > 10 | 10 | 8 |  |
Mitotic index (per 50 HPFs)* | |||
 0–5 | 76 | 31 | 0.002 |
  > 5 | 35 | 37 |  |
Modified NIH criteria* | |||
 Very low/low | 48 | 18 | 0.011 |
 Intermediate | 22 | 9 |  |
 High | 41 | 41 |  |