Fig. 6
From: THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
CDK7 inhibition leads to the suppression of RNA transcription in GIST cells. A Heatmap showing the change in global active transcripts in GIST-T1 cells following treatment with 50Â nmol THZ1 and DMSO for 6Â h. B Heatmap showing the transcriptional changes in cell cycle-related genes from the gene set (GOBP_CELL_CYCLE.v7.5.1) in GIST-T1 cells after THZ1 treatment. C The enriched GO functional terms of the transcripts that were reduced over twofold in GIST-T1 cells following treatment with 50Â nmol/L THZ1 for 6Â h. D Immunoblot analyses of RNAPII, RNAPII CTD phosphorylation (S2, S5, and S7), and CDK7 in GIST-T1 and GIST-882 cells treated either with THZ1 or DMSO at the indicated concentrations for 24Â h