Fig. 1
From: THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
High CDK7 protein expression is associated with a poor prognosis of GIST. A Based on data from the GSE136755 dataset, the mRNA levels of CDK4, CDK7 and CDK9 were relatively higher than those of other CDKs for CDK1-10. The mRNA level was calculated via GEO2R. B CDK7 expression was significantly elevated in high-risk GISTs based on the data from GSE136755. C Representative scanned images of GIST samples with low or high CDK7 protein expression, as determined by IHC. D Kaplan–Meier survival curves with a risk table showing that high CDK7 protein expression was significantly positively related to poor recurrence-free survival in GIST patients (P = 0.044)