Fig. 2
From: CCM signaling complex (CSC) couples both classic and non-classic Progesterone receptor signaling
Prognostic effects for key CmPn players utilizing microarray data of breast cancer patients. Publicly available microarray data from breast cancer patients was analyzed using either kmplotter or Xena browser (TCGA database) to integrate gene expression and clinical data simultaneously to generate the displayed Kaplan–Meier (KM) survival curves. A Prognostic effects [Overall survival (OS)] for CSC expression in Luminal-A type breast cancers using kmplotter. B OS for mPRs/nPRs expression in Luminal-A type breast cancers using kmplotter. C OS for mPRs expression in Luminal-A type breast cancers using TCGA. D OS for CSC expression in Luminal-A type breast cancers using TCGA. Logrank P-values are calculated and displayed as well as hazard ratio (and 95% confidence intervals) for panels A–B automatically calculated by the software using default parameters. Logrank P-values are calculated and displayed as well as logrank test statistics for panels C–D automatically calculated by the software using default parameters. Red line demonstrates high gene expression (all panels), while black line (panels A–B) or blue line (panels C–D) demonstrates low gene expression