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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: SENP1 regulates the transformation of lung resident mesenchymal stem cells and is associated with idiopathic pulmonary fibrosis progression

Fig. 6

LR-MSCs with SENP1 downregulation attenuate pulmonary fibrosis. A In vivo imaging of GFP + LR-MSCs after transplantation. B The expression of α-SMA and Collagen I in mouse lung tissues was analyzed using western blotting in vivo. Quantification is shown in the right panel. C The effect of LR-MSCs (LV-SENP1-shRNA) on pulmonary fibrotic lesions was determined using hematoxylin–eosin (H&E) staining and Masson staining. Scale bar, 50 μm. Representative data are shown. Quantification is shown in the right panel. *P < 0.01, ▲P > 0.05, **P < 0.05. *, the control group vs. the BLM group; ▲, the LR-MSCs (scramble-shRNAs) group vs. the BLM group; **, the LR-MSCs (LV-SENP1-shRNA) group vs. the BLM group. The results are shown as the means ± SD

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Cell Communication and Signaling

ISSN: 1478-811X