Fig. 2

Epistasis analysis indicates that nhr-14/HNF4 mediated DNA damage-induced apoptosis. A Quantitative analysis of germ cell apoptosis induced by gamma-irradiation in N2, nhr-14(tm1473), akt-1(ok525) and akt-1(ok525); nhr-14(tm1473). Young adult animals were irradiated with gamma-ray (120 Gy) and analyzed at indicated time points after irradiation. Error bars represent standard error of the mean (SEM). B Quantitative analysis of germ cell apoptosis induced by gamma-irradiation in N2, nhr-14(tm1473), brc-1(tm1145) and brc-1(tm1145); nhr-14(tm1473) animals. D Quantitative analysis of germ cell apoptosis induced by gamma-irradiation in N2, nhr-14(tm1473), ced-9(n1653) and ced-9(n1653); nhr-14(tm1473) animals. C Quantitative analysis of germ cell apoptosis in control RNAi and nhr-14 RNAi-treated N2 and abl-1(ok171) animals. N2 and abl-1(ok171) were fed with control RNAi and nhr-14 RNAi and then (L4) was irradiated at 120 Gy. After 36 h of gamma-irradiation, germ cell apoptosis from one gonad arm of each animal were scored from at least 20 animals. Error bars represent standard error of the mean (SEM). D Quantitative analysis of germ cell apoptosis induced by gamma-irradiation in N2, nhr-14(tm1473), brc-1(tm1145) and brc-1(tm1145); nhr-14(tm1473) animals