Fig. 1
From: Exosomes-based therapy of stroke, an emerging approach toward recovery
Intracellular machinery component of exosome (Exo) (A). biogenesis. Exo are generated inside endosomal vesicles. The maturation of early endosomes into multivesicular bodies (MVBs) leads to the formation of numerous intraluminal vesicles (ILVs). In the next steps, MVBs can be directed to lysosomal digestion and/or transformed into later endosomes which can fuse with the cell membrane. Upon release of ILVs into ECM, they are named Exo. Exo structure and cargo (B). Exo possess a Lipid bilayer with several ligands and receptors. Exo can transfer several signaling molecules such as lipids, proteins, and enzymes