Fig. 1
From: Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis
Schematic depicting the domain of BRAF and MAP2K1, and major mutations identified in LCH. A BRAF comprises three main domains, the RAS-binding domain (120–280 amino acids), hinge domain, and kinase domain (457–717 amino acids). V600 mutation belongs to class I BRAF mutation, resulting in an activated monomer of the Braf molecule. The N486_P490del mutation results in a shortened β3-αC3 loop of the Braf molecule. B MAP2K1 comprises three main domains, the ERK-binding domain (EBD), negative-regulatory domain (NRR), and kinase domain (68–361 amino acids). MAP2K1 mutations found in LCH were mainly class II (RAF-regulated) and class III (RAF-independent) mutations