Fig. 4
From: Putting human Tid-1 in context: an insight into its role in the cell and in different disease states
hTid-1 in the regulation of cancer-associated proteins. A hTid-1enhances the attachment of pVHL with HIF-1α which increases the attachment of poly-ubiquitin chains to HIF-1α, and its subsequent degradation via the proteasomal pathway. B hTid-1 interacts with both Wild-Type and mutant p53, causing the translocation of p53 into the mitochondria and subsequent apoptosis via the intrinsic pathway. C Upon HGF stimulation, hTid-1 interacts with the Met protein causing its dissociation from the Met Receptor, and an increase in cellular proliferation. D hTid-1 along with CHIP causes the degradation of ErBb2. E hTid-1 interacts with STAT5b and stops cell growth